Jim's Articles

Les mieux notés trucs et astuces de rencontres occasionnelles proche de moi

Les mieux notés guider de rencontres amicales Limoges? Fixez des limites saines – même avant de vous rencontrer : Il est naturel de flirter via des messages et des conversations au début de la rencontre. Vous poursuivez une relation amoureuse, après tout ! Cependant, si votre rendez-vous dépasse les limites et vous met mal à l’aise, faites-le lui savoir poliment immédiatement. Par exemple, s’il fait une avance qui semble trop, trop tôt, exprimez vos sentiments : « Cela me met mal à l’aise, pourrions-nous prendre du recul, s’il vous plaît ? Trouver additionnel info sur www.escortlimoges.com.

Il y a quelque chose à propos de la fin d’une année et du début d’une nouvelle qui vous incite naturellement à faire le point sur vos anciennes habitudes et à en adopter de plus intelligentes. Ce phénomène bien documenté s’appelle «l’effet nouveau départ» – des repères, comme une nouvelle année, motivent les gens à se fixer des objectifs. Si votre objectif consiste à trouver comment trouver l’amour en 2022, j’ai une nouvelle pour vous : vous n’avez pas à passer des heures à balayer sans relâche ces applications de rencontres pour atteindre ce bonheur pour toujours. En fait, bon nombre des meilleurs conseils de rencontres que j’ai à offrir n’ont rien à voir avec la recherche d’autres célibataires, mais plutôt avec un travail sur vous-même. Plus vous consacrez de temps et d’efforts à examiner et à changer les schémas qui vous maintiennent “coincé”, plus vous avez de chances de reconnaître le véritable amour avec un potentiel durable lorsque vous le trouvez. Bref, il est temps de se replier sur soi. Quels défauts peuvent vous empêcher d’attirer le partenaire que vous désirez ? Quelles croyances ou tendances malsaines vous poussent vers les personnes toxiques ? Comment pouvez-vous vous construire pour avoir la confiance nécessaire pour poursuivre ce que vous voulez et la résilience pour gérer le rejet lorsque cela ne fonctionne pas ?

Le but d’aller à des rendez-vous, de parler à de nouvelles personnes et de vous ouvrir pour rencontrer quelqu’un de nouveau n’est pas de nourrir votre ego, d’affirmer des insécurités ou de trouver une âme sœur dès que possible. Le but est de collecter des informations qui vous rapprocheront d’une vie heureuse et épanouie et de passer un bon moment en cours de route. Bottom line: Cela devrait être amusant de rencontrer de nouvelles personnes, qu’un deuxième rendez-vous suive ou non. Si ce n’est pas le cas, faites une pause pour réfléchir à ce que vous recherchez vraiment dans votre vie amoureuse.

Il est toujours difficile de s’y retrouver dans les rencontres : qu’est-ce que vous répondez par SMS, qui paie le chèque et pourquoi est-il si difficile de rencontrer des gens normaux ? Mais sortir ensemble en 2022 apporte une toute nouvelle série de difficultés : les anciennes règles de rencontres ne s’appliquent plus, la plupart des échanges se font via une application, et nous avons oublié comment nous maquiller en restant à la maison depuis 2020 (non, juste moi ?). Mais difficile ou pas, vous méritez une vie épanouie, des façons amusantes de rencontrer de nouvelles personnes et de vraiment profiter des rencontres (parce que personne ne devrait avoir l’épuisement amoureux de Charlotte).

Ne… renvoyez pas quelqu’un après un seul rendez-vous ! Au lieu de tirer une conclusion hâtive, considérez que l’autre personne a peut-être été extrêmement nerveuse ou qu’elle a simplement passé une mauvaise journée. À moins qu’il ne soit évident que les choses ne fonctionneront pas, organisez un deuxième rendez-vous pour vraiment avoir une idée de cette autre personne. De nombreux mariages réussis ont tous commencé par un mauvais premier rendez-vous ! Qui sait, vous pourriez être l’un d’entre eux aussi, un jour. Soyez… aventureux ! Quand il s’agit de planifier une date, sortez des sentiers battus et réservez une activité que vous n’avez jamais faite auparavant. Besoin d’inspiration ? Abonnez-vous à la liste de diffusion @made_my_date et laissez votre boîte de réception se remplir d’idées de rencontres amusantes.

Si vous n’êtes pas satisfait de votre vie amoureuse, je peux vous garantir une chose : vous êtes probablement tombé dans un schéma qui ne vous sert plus. Certains célibataires aiment blâmer les autres pour leur manque de succès – “Il n’y a plus de bons hommes célibataires!” ou “Je semble juste attirer les femmes superficielles!” – mais la réalité est qu’il est temps de commencer à assumer la responsabilité de vos propres habitudes d’auto-sabotage. Cela peut ressembler à un conte de fées au premier abord. Une semaine plus tard, ils prévoient déjà un week-end romantique, et au troisième rendez-vous, ils prononcent ces trois petits mots. Mais voici la vérité : quand quelqu’un pousse votre relation à se déplacer à une vitesse fulgurante, c’est en fait un gros drapeau rouge.

Best travelling guides and products shopping reviews

Premium hunting products and advices? While outdoor lovers may savor the primitive appeal of “getting back to nature,” the products we’re taking with us are more high-tech than ever. Just witness some of the category’s coolest recent launches, including custom snow goggles, carbon-plated trail runners and an insulated jacket made from ocean plastic. Now relax, cave people: our list still has room for a butt pad, a camp shoe and a machete. But true to the thrust of the industry, this machete folds. By combining our own real-world experiences and expertise with extensive market research, we are able to combine both qualitative and quantitative factors that would be incredibly time-consuming for the typical consumer to do on their own. Read additional info on cracker barrel front porch.

Outdoor kitchens are a backyard bonus. And outdoor kitchen kits make it easy to customize your design and respect your budget. What is an Outdoor Kitchen Kit? If you’re serious about backyard dining and entertaining, you may be considering an outdoor kitchen. Usually composed of a sink, grilling area, refrigerator and bar area, outdoor kitchens extend the living space of your home and transform your backyard into a place for easy, stress-free cooking and dining. But if you’ve priced outdoor kitchens, you may have experienced sticker shock. Custom-built kitchens typically start at around $10,000 and go up from there — by a lot. For the DIYer with some basic skills, an outdoor kitchen kit can be a more affordable option, usually with a few simple hook-ups. While you can still spend big bucks on an outdoor kitchen kit, the options allow you to pretty much name your price.

The detectors cost a lot because of their vulnerability to various environmental conditions, high power consumption, low mass production stability, and integration issues. Since the production of detectors requires high platform costs, the investment in technology research and development is also a sizeable continuous investment. The improvement of each parameter means the upgrade of the entire system. There is still much room for improvement in core indicators such as NETD, pixel pitch, and magnification, which leads manufacturers to continue to research and upgrade to ensure that they will not significantly lag behind their competitors.

In heat guns, temperature matters quite a lot. That’s one of the primary reasons why the #1 Wagner Spraytech HT1000 is considered the best heat gun currently on the market; it can produce up to 1,000°F temperatures at the nozzle. The higher the temperature setting, the more heavy-duty tasks you can do with a heat gun. The most intense task you can do is paint removal; in that case the most powerful #2 SEEKONE ‎SDL-2816 with 1,200°F comes in handy. Note: Temperature output is standardly measured 0.4 mm away from the nozzle after 340 seconds at the set temperature setting. The #1 Wagner Spraytech HT1000 is so versatile because it has a dual-temp setting (750°F / 1,000°F). With that range, you can do all heavy-duty tasks like vinyl wrapping, caulking removal, adhesive removal, plastic pipes bending, paint removal and even loosening nuts and bolts.

This Jeep Wrangler underglow rock light assembly provides me with enough light pods to have them installed to both the front and rear bumpers. I had to buy an extension cable separately, however, to get to the rear of the Jeep, which wasn’t a big deal as they didn’t cost a fortune. Installation wasn’t the easiest I had attempted, but with the in-depth instructions that come with the product, I got it properly installed in the end. The light pods are of high quality, having shown no issues with water, dust or corrosion. As they’re easy to care for, and I do care for them regularly, the brightness is still as strong as when I first bought and installed the lights. They serve their main purpose well and work as anticipated, helping to keep my vision sharp during my night-time off-road trips. The 3rd gen Bluetooth was easy and fast to connect. It works better than what comes with most other light kits. Through this Bluetooth, I could control the lights and the many functions they offer including blinking, flashing, and the degree of brightness. Read more details at https://fixoutdoor.com/.

Latest reconstructive transplantation research studies from Karim Sarhane

Peripheral nerve regeneration research by Karim Sarhane 2022? Insulin-like growth factor 1 (IGF-1) is a hormone produced by the body that has the potential to be used as a treatment for nerve injuries. IGF-1 may help heal nerve injuries by decreasing inflammation and buildup of damaging products. Additionally, it may speed up nerve healing and reduce the effects of muscle weakness from the injury. However, a safe, effective, and practical way is needed to get IGF-1 to the injured nerve.

Dr. Karim Sarhane is an MD MSc graduate from the American University of Beirut. Following graduation, he completed a 1-year internship in the Department of Surgery at AUB. He then joined the Reconstructive Transplantation Program of the Department of Plastic and Reconstructive Surgery at Johns Hopkins University for a 2-year research fellowship. He then completed a residency in the Department of Surgery at the University of Toledo (2021). In July 2021, he started his plastic surgery training at Vanderbilt University Medical Center. He is a Diplomate of the American Board of Surgery (2021).

Peripheral nerve injury subjects muscle to prolonged denervation that results in myofiber atrophy with increased proteolysis, decreased contractility, and interstitial fibrosis. As the period of denervation extends, these proteolytic and fibrotic processes continue, thereby decreasing the viability of muscle to accept regenerating axons (Shavlakadze et al., 2005; Tuffaha et al., 2016b). In addition to the deleterious effects of prolonged denervation and fibrosis on muscle, functional recovery is hindered by the failure of regenerating motor nerve fibers to come into contact with the specific motor pathways that guide them back to their original motor endplates (Gordon, 2020). A more thorough description of the biological processes and pathways implicated in denervation-induced muscle atrophy can be found in this recent review article by Ehmsen and Hoke (2020). Following nerve injury, local levels of IGF-1 increase and stimulate axonal sprouting into denervated muscle (Homs et al., 2014). IGF-1 also activates the Akt/mTOR pathway, thereby decreasing atrophy markers including MAFbx and MuRF1 (Bodine et al., 2001; Stitt et al., 2004). Also of note, IGF-1’s propensity for decreasing inflammation via promotion of a pro-regenerative M2 macrophage shift over pro-inflammatory M1 reduces the degree of scarring and fibrosis that could otherwise interfere with the targeting of regenerating motor axons (Labandeira-Garcia et al., 2017; Zhao et al., 2021).

Effects with sustained IGF-1 delivery (Karim Sarhane research) : Functional recovery following peripheral nerve injury is limited by progressive atrophy of denervated muscle and Schwann cells (SCs) that occurs during the long regenerative period prior to end-organ reinnervation. Insulin-like growth factor 1 (IGF-1) is a potent mitogen with well-described trophic and anti-apoptotic effects on neurons, myocytes, and SCs. Achieving sustained, targeted delivery of small protein therapeutics remains a challenge.

Insulin-like growth factor-1 (IGF-1) is a particularly promising candidate for clinical translation because it has the potential to address the need for improved nerve regeneration while simultaneously acting on denervated muscle to limit denervation-induced atrophy. However, like other growth factors, IGF-1 has a short half-life of 5 min, relatively low molecular weight (7.6 kDa), and high water-solubility: all of which present significant obstacles to therapeutic delivery in a clinically practical fashion (Gold et al., 1995; Lee et al., 2003; Wood et al., 2009). Here, we present a comprehensive review of the literature describing the trophic effects of IGF-1 on neurons, myocytes, and SCs. We then critically evaluate the various therapeutic modalities used to upregulate endogenous IGF-1 or deliver exogenous IGF-1 in translational models of PNI, with a special emphasis on emerging bioengineered drug delivery systems. Lastly, we analyze the optimal dosage ranges identified for each mechanism of IGF-1 with the goal of further elucidating a model for future clinical translation.

Patients who sustain peripheral nerve injuries (PNIs) are often left with debilitating sensory and motor loss. Presently, there is a lack of clinically available therapeutics that can be given as an adjunct to surgical repair to enhance the regenerative process. Insulin-like growth factor-1 (IGF-1) represents a promising therapeutic target to meet this need, given its well-described trophic and anti-apoptotic effects on neurons, Schwann cells (SCs), and myocytes. Here, we review the literature regarding the therapeutic potential of IGF-1 in PNI. We appraised the literature for the various approaches of IGF-1 administration with the aim of identifying which are the most promising in offering a pathway toward clinical application. We also sought to determine the optimal reported dosage ranges for the various delivery approaches that have been investigated.

Best technology online magazine

Tech blog 2022? As their name suggests, contactless stores use advanced technology to enable a seamless, touch-free shopping experience. The goal is to minimize the amount of contact or friction a customer would typically experience in a traditional shop. One of the most well-known examples of a contactless store is Amazon Go. Amazon Go locations use advanced Just Walk Out technology — including computer vision, sensor fusion and deep learning. Customers scan a barcode to enter the store, take the items they need and walk out. The technology monitors what people take off shelves and add them to a customer’s virtual shopping cart. After they leave the store, they pay using a pre-saved payment method. See even more details at technology news.

AI and machine learning are familiar technologies that have been gaining momentum for years. However, there will be a breakthrough in AI and machine learning in the second half of this year. We can already see traces of said breakthrough in the recent stories about the famous Google AI, LaMDA, which is rumored to have become sentient. The energy tech industry is the solution for energy creation in the future, but it doesn’t have enough stakeholder support because it aims to create alternatives to traditional energy creation. But we will see more widespread support and breakthrough in the energy tech industry this year. We will be able to develop alternative energy supplies such as green hydrogen that don’t compound our climate problems, and these alternatives will power our planes, ships, trains, and more.

Check the GPS tracker working current: Working current is not easy to confirm. Here are several cases, in a nutshell: Sleep current when stationary; GPS and GSM ON current; GSM ON current; GSM and WIFI ON current; Here we mainly analyze the most common sleep current and GSM+GPS fully working current. Sleep current has a great matter in the engineering and components of tracing devices, mainly 2 types: Wireless vehicle tracking device: MCU+2G GSM module+GPS module and Personal or pet GPS tracker: 2G GSM chip+ GPS chip (mainly MTK6261, MTk2503 GSM chips).

Tweak a few settings and it will do wonders for boosting the battery life of the phone. These include turning off Wi-Fi and Bluetooth when not in use, turning the brightness down, and turning off vibration mode for notifications. It is also essential to clean the battery and battery posts on the handsets, as sediments tend to build up on these parts. Further, allow the battery to complete its discharging cycle. Refrain from charging it daily, unless there is an emergency.

Google Sheets is more powerful than Gmail contacts. Google Sheets let you merge and filter your contacts according to any criteria- like business or personal. See the demo app below. The shared app can be embedded within a website or launched as a web app. Additionally, the app can be launched as a mobile app. It’s connected to Google Sheets, so you can update your contacts both in the app and on the spreadsheet.

Our GPS Tracking software www.demogps.com is one of the most advanced one in the world offering hundreds of features beside Real time tracking and History Playback. If you are choosing software, please look into features clearly and compare with our gps tracking software features: Geo-fence, Email alert, Image monitoring, Fuel Monitoring, Vehicle maintenance alert, mutli-level user account manage. We offer customized login page according to clients, specially for those supply GPS tracking business locally. Having a brand GPS tracking software shows the company ability to offer high standard service. We offer customized login page as below: Branded Domain, Branded Login Page, Branded Logo.

The phone world is one of the most fierce battlegrounds in tech, with giants like Apple and Samsung constantly trying to outdo each other with the latest, greatest devices. Their newest flagships, the iPhone 12 and Galaxy S21, respectively, offer fantastic rear multicamera setups, powerful processors, wireless charging and 5G. But they’re not the only brands to consider, with other rivals such as OnePlus, Motorola and Google’s Pixel line all offering great specs at a range of prices. The sheer amount of solid competition gives us great options to choose from at a range of prices, regardless of whether your biggest concern is high speed data, an AMOLED display or a selfie camera. Opting for a more affordable handset doesn’t mean compromising on usability, with even budget handsets offering big, vibrant displays and multiple rear cameras. We’re even starting to see 5G connectivity on much lower-end handsets. Find additional details at parcian.tech.

Professional ICU nurse responsibilities guides with Tene Kishan Los Angeles, California

High quality critical care nurse skills advices from Tene Kishan Los Angeles, California? Tene Kishan has a background in health care and public administration. She earned 3 college degrees and has a Bachelor’s of Arts Degree in political science, a Bachelor’s of Science in nursing and a Master’s Degree in public administration. Tene Kishan is Registered Nurse with a background in ICU/Critical Care and owns a non-profit organization that’s provides services and puts on community events for youth in need of housing services in the area of Los Angeles County.

How To Become a Registered Nurse In The ICU? If you’re interested in becoming a registered nurse in the icu, one of the first things to consider is how much education you need. We’ve determined that 48.4% of registered nurse in the icus have a bachelor’s degree. In terms of higher education levels, we found that 6.3% of registered nurse in the icus have master’s degrees. Even though most registered nurse in the icus have a college degree, it’s possible to become one with only a high school degree or GED.

Tene Kishan about ICU nurse careers: What do ICU nurses do? ICU nurses work in challenging and complex fields in their nursing profession. They have the primary duty to provide lifesaving care to patients fighting for their lives. They are highly trained to provide exceptional care for patients who depend on 24/7 nursing care. A patient in ICU is often ventilated, intubated, and can be on several life-saving machines and medications. ICU nurses are at the top of their game and well-versed with all aspects of specialized care to restore their patients’ health and wellness. Some of the specific responsibilities of ICU nurses include: Evaluating and monitoring of patient’s progress and identification of any sudden or subtle changes in the patient’s medical condition. Administering medications intravenously by injection or via gastric tubes.

To deliver highly skilled care, critical care nurses undertake postgraduate study and ongoing training. The Step Competency Framework underpins critical care nurse education; it recognises that, to be able to deliver high-quality care to patients, staff need the knowledge and skills so they can work at the highest level, with standardisation across all critical care units. Step 1 for adult critical care begins when a nurse with no previous experience of the specialty starts working in intensive care medicine. Steps 2 and 3 should be incorporated into academic intensive care programmes.

Duties and Responsibility of ICU nurse: Direct and supervise less-skilled nursing/health care personnel, or supervise a particular unit on one shift to patient’s response and conditions. Treating wounds and providing advanced life support. Assist physicians with procedures such as bronchoscopy, endoscopy, endotracheal intubation, and elective cardioversion. Ensuring that ventilators, monitors, and other types of medical equipment function properly. Ensure that equipment or devices are properly stored after use. Identify malfunctioning equipment or devices. Collaborating with fellow members of the critical care team. Responding to life-saving situations, using nursing standards and protocols for treatment. Read extra details on Tene Kishan.

Sustained IGF-1 delivery research and science with Karim Sarhane today

Peripheral nerve regeneration research studies with Karim Sarhane 2022? We performed a study with rodents and primates that showed this new delivery method provided steady release of IGF-1 at the target nerve for up to 6 weeks,” Dr. Karim Sarhane reported. Compared to animals without this hormone treatment, IGF-1 treated animals (rodents and primates) that were injected every 6 weeks showed a 30% increase in nerve recovery. This has the potential to be a very meaningful therapy for patients with nerve injuries. Not only do these results show increased nerve recovery but receiving a treatment every 6 weeks is much easier on a patient’s lifestyle than current available regiments that require daily treatment.

Dr. Karim Sarhane is an MD MSc graduate from the American University of Beirut. Following graduation, he completed a 1-year internship in the Department of Surgery at AUB. He then joined the Reconstructive Transplantation Program of the Department of Plastic and Reconstructive Surgery at Johns Hopkins University for a 2-year research fellowship. He then completed a residency in the Department of Surgery at the University of Toledo (2021). In July 2021, he started his plastic surgery training at Vanderbilt University Medical Center. He is a Diplomate of the American Board of Surgery (2021).

A number of in vitro studies have highlighted the neurotrophic effects of IGF-1 (Table 1). Using cultured nerve, SCs, and dorsal root ganglion (DRG) cells, these studies demonstrate that IGF-1 promotes neurite outgrowth and limits neuronal apoptosis (Caroni and Grandes, 1990; Sumantran and Feldman, 1993; Akahori and Horie, 1997; Delaney et al., 2001; Ogata et al., 2004; Liang et al., 2007; Scheib and Hoke, 2013, 2016a,b). Additionally, several in vitro studies have shown that IGF-1 supports SC myelination and inhibits SC apoptosis whilst also stimulating nerve sprouting into denervated muscle and reducing muscle atrophy (Caroni and Grandes, 1990; Sumantran and Feldman, 1993; Ogata et al., 2004; Liang et al., 2007; Scheib and Hoke, 2016a,b).

Recovery with sustained IGF-1 delivery (Karim Sarhane research) : The translation of NP- mediated delivery of water-soluble bioactive protein therapeutics has, to date, been limited in part by the complexity of the fabrication strategies. FNP is commonly used to encapsulate hydrophobic therapeutics, offering a simple, efficient, and scalable technique that enables precise tuning of particle characteristics [35]. Although the new iFNP process improves water-soluble protein loading, it is difficult to preserve the bioactivity of encapsulated proteins with this method.

Patients who sustain peripheral nerve injuries (PNIs) are often left with debilitating sensory and motor loss. Presently, there is a lack of clinically available therapeutics that can be given as an adjunct to surgical repair to enhance the regenerative process. Insulin-like growth factor-1 (IGF-1) represents a promising therapeutic target to meet this need, given its well-described trophic and anti-apoptotic effects on neurons, Schwann cells (SCs), and myocytes. Here, we review the literature regarding the therapeutic potential of IGF-1 in PNI. We appraised the literature for the various approaches of IGF-1 administration with the aim of identifying which are the most promising in offering a pathway toward clinical application. We also sought to determine the optimal reported dosage ranges for the various delivery approaches that have been investigated.

Patients who sustain peripheral nerve injuries (PNIs) are often left with debilitating sensory and motor loss. Presently, there is a lack of clinically available therapeutics that can be given as an adjunct to surgical repair to enhance the regenerative process. Insulin-like growth factor-1 (IGF-1) represents a promising therapeutic target to meet this need, given its well-described trophic and anti-apoptotic effects on neurons, Schwann cells (SCs), and myocytes. Here, we review the literature regarding the therapeutic potential of IGF-1 in PNI. We appraised the literature for the various approaches of IGF-1 administration with the aim of identifying which are the most promising in offering a pathway toward clinical application. We also sought to determine the optimal reported dosage ranges for the various delivery approaches that have been investigated.