Category: Health

High quality anxiety specialist Melbourne? The combination of focusing-oriented somatic psychotherapy with talk therapy, our work together helps integrate the emotional landscape, as well as the body’s neurological nervous system. This integration allows for a shift in unhealthy habits, limiting patterns, and unhealthy boundaries, allowing the body’s nervous system to resolve itself back to its natural home – your authentic self. The body has its own internal wisdom. We are so accustomed to using our mind to navigate the word, that when guided correctly, we discover a whole world beneath the surface that is so often ignored. Using somatic based focusing psychotherapy we can tune in and truly listen, perhaps for the first time. This can create something truly profound. See extra info at therapist Melbourne.

How Long Does it Take to Detox from Alcohol at Home? The amount of time it takes to detox from alcohol depends on several factors, including whether you’re detoxing at home or with medical supervision. Detoxing at home usually takes longer because you should be cautious to avoid serious complications. When you are detoxing from alcohol at a rehab center, nurses and doctors monitor vital signs, provide adequate nourishment and treat complications if they occur. Alcohol can stay in your system for several hours depending on how much you drink. Once it begins to leave your body, early symptoms of withdrawal begin.

Several studies suggest that mindfulness meditation can benefit those who struggle with stress, anxiety and depression issues. A literature review conducted in 2014 assessed 47 mindfulness meditation trials that involved around 3,515 participants. The review concluded that meditation is a useful tool that helps relieve symptoms of anxiety and depression. And not only do meditators feel less stressed, their levels of the “stress hormone” cortisol decrease measurably. Chogyal Rinpoche, a spiritual leader and meditation expert, explains how meditation gradually calms the mind and prevents strong emotions from erupting uncontrollably. So rather than allowing themselves to be overcome by depression and stress, meditators learn to calm their minds and achieve balance.

By learning to navigate, relate, and explore to emotions that are in the body, we can experience what is known as a “felt shift”. Somatic Therapy, releases trauma from the body that is “trapped”. The sensation when the body returns to back to its resting place can be very liberating. The end result, is a therapy that get’s to the core problem much faster. This allows for changes occur at the neurobiological level. This combined with traditional talk therapy also creates change at the cognitive and behavioural levels as well.

Sometimes when we take on lots of projects, we can feel invincible. Yet, as the days and months creep up on us, juggling all these extra tasks, can take its toll. Adding a pandemic to the mix, and juggling looking after kids, homeschooling, and everything else that comes along with it, can be all consuming. Thankfully, there are some great tools to manage stress, such as eating healthy and exercise. Also, there’s learning time management skills, delegating, and meditating can also help. But sometimes, no matter how hard we try, these are all nice ideas, but seemingly impossible to do. Something deeper may be at play. If you’ve found yourself in this running rat cycle for a bit too long, it might be time to get a fresh look at what’s going on. Find additional information on ronnieadamowicz.com.

Peripheral nerve regeneration research by Karim Sarhane 2022? Insulin-like growth factor 1 (IGF-1) is a hormone produced by the body that has the potential to be used as a treatment for nerve injuries. IGF-1 may help heal nerve injuries by decreasing inflammation and buildup of damaging products. Additionally, it may speed up nerve healing and reduce the effects of muscle weakness from the injury. However, a safe, effective, and practical way is needed to get IGF-1 to the injured nerve.

Dr. Karim Sarhane is an MD MSc graduate from the American University of Beirut. Following graduation, he completed a 1-year internship in the Department of Surgery at AUB. He then joined the Reconstructive Transplantation Program of the Department of Plastic and Reconstructive Surgery at Johns Hopkins University for a 2-year research fellowship. He then completed a residency in the Department of Surgery at the University of Toledo (2021). In July 2021, he started his plastic surgery training at Vanderbilt University Medical Center. He is a Diplomate of the American Board of Surgery (2021).

Peripheral nerve injury subjects muscle to prolonged denervation that results in myofiber atrophy with increased proteolysis, decreased contractility, and interstitial fibrosis. As the period of denervation extends, these proteolytic and fibrotic processes continue, thereby decreasing the viability of muscle to accept regenerating axons (Shavlakadze et al., 2005; Tuffaha et al., 2016b). In addition to the deleterious effects of prolonged denervation and fibrosis on muscle, functional recovery is hindered by the failure of regenerating motor nerve fibers to come into contact with the specific motor pathways that guide them back to their original motor endplates (Gordon, 2020). A more thorough description of the biological processes and pathways implicated in denervation-induced muscle atrophy can be found in this recent review article by Ehmsen and Hoke (2020). Following nerve injury, local levels of IGF-1 increase and stimulate axonal sprouting into denervated muscle (Homs et al., 2014). IGF-1 also activates the Akt/mTOR pathway, thereby decreasing atrophy markers including MAFbx and MuRF1 (Bodine et al., 2001; Stitt et al., 2004). Also of note, IGF-1’s propensity for decreasing inflammation via promotion of a pro-regenerative M2 macrophage shift over pro-inflammatory M1 reduces the degree of scarring and fibrosis that could otherwise interfere with the targeting of regenerating motor axons (Labandeira-Garcia et al., 2017; Zhao et al., 2021).

Effects with sustained IGF-1 delivery (Karim Sarhane research) : Functional recovery following peripheral nerve injury is limited by progressive atrophy of denervated muscle and Schwann cells (SCs) that occurs during the long regenerative period prior to end-organ reinnervation. Insulin-like growth factor 1 (IGF-1) is a potent mitogen with well-described trophic and anti-apoptotic effects on neurons, myocytes, and SCs. Achieving sustained, targeted delivery of small protein therapeutics remains a challenge.

Insulin-like growth factor-1 (IGF-1) is a particularly promising candidate for clinical translation because it has the potential to address the need for improved nerve regeneration while simultaneously acting on denervated muscle to limit denervation-induced atrophy. However, like other growth factors, IGF-1 has a short half-life of 5 min, relatively low molecular weight (7.6 kDa), and high water-solubility: all of which present significant obstacles to therapeutic delivery in a clinically practical fashion (Gold et al., 1995; Lee et al., 2003; Wood et al., 2009). Here, we present a comprehensive review of the literature describing the trophic effects of IGF-1 on neurons, myocytes, and SCs. We then critically evaluate the various therapeutic modalities used to upregulate endogenous IGF-1 or deliver exogenous IGF-1 in translational models of PNI, with a special emphasis on emerging bioengineered drug delivery systems. Lastly, we analyze the optimal dosage ranges identified for each mechanism of IGF-1 with the goal of further elucidating a model for future clinical translation.

Patients who sustain peripheral nerve injuries (PNIs) are often left with debilitating sensory and motor loss. Presently, there is a lack of clinically available therapeutics that can be given as an adjunct to surgical repair to enhance the regenerative process. Insulin-like growth factor-1 (IGF-1) represents a promising therapeutic target to meet this need, given its well-described trophic and anti-apoptotic effects on neurons, Schwann cells (SCs), and myocytes. Here, we review the literature regarding the therapeutic potential of IGF-1 in PNI. We appraised the literature for the various approaches of IGF-1 administration with the aim of identifying which are the most promising in offering a pathway toward clinical application. We also sought to determine the optimal reported dosage ranges for the various delivery approaches that have been investigated.

High quality critical care nurse skills advices from Tene Kishan Los Angeles, California? Tene Kishan has a background in health care and public administration. She earned 3 college degrees and has a Bachelor’s of Arts Degree in political science, a Bachelor’s of Science in nursing and a Master’s Degree in public administration. Tene Kishan is Registered Nurse with a background in ICU/Critical Care and owns a non-profit organization that’s provides services and puts on community events for youth in need of housing services in the area of Los Angeles County.

How To Become a Registered Nurse In The ICU? If you’re interested in becoming a registered nurse in the icu, one of the first things to consider is how much education you need. We’ve determined that 48.4% of registered nurse in the icus have a bachelor’s degree. In terms of higher education levels, we found that 6.3% of registered nurse in the icus have master’s degrees. Even though most registered nurse in the icus have a college degree, it’s possible to become one with only a high school degree or GED.

Tene Kishan about ICU nurse careers: What do ICU nurses do? ICU nurses work in challenging and complex fields in their nursing profession. They have the primary duty to provide lifesaving care to patients fighting for their lives. They are highly trained to provide exceptional care for patients who depend on 24/7 nursing care. A patient in ICU is often ventilated, intubated, and can be on several life-saving machines and medications. ICU nurses are at the top of their game and well-versed with all aspects of specialized care to restore their patients’ health and wellness. Some of the specific responsibilities of ICU nurses include: Evaluating and monitoring of patient’s progress and identification of any sudden or subtle changes in the patient’s medical condition. Administering medications intravenously by injection or via gastric tubes.

To deliver highly skilled care, critical care nurses undertake postgraduate study and ongoing training. The Step Competency Framework underpins critical care nurse education; it recognises that, to be able to deliver high-quality care to patients, staff need the knowledge and skills so they can work at the highest level, with standardisation across all critical care units. Step 1 for adult critical care begins when a nurse with no previous experience of the specialty starts working in intensive care medicine. Steps 2 and 3 should be incorporated into academic intensive care programmes.

Duties and Responsibility of ICU nurse: Direct and supervise less-skilled nursing/health care personnel, or supervise a particular unit on one shift to patient’s response and conditions. Treating wounds and providing advanced life support. Assist physicians with procedures such as bronchoscopy, endoscopy, endotracheal intubation, and elective cardioversion. Ensuring that ventilators, monitors, and other types of medical equipment function properly. Ensure that equipment or devices are properly stored after use. Identify malfunctioning equipment or devices. Collaborating with fellow members of the critical care team. Responding to life-saving situations, using nursing standards and protocols for treatment. Read extra details on Tene Kishan.

Top Agraphobia (Contreltophobia) tricks and tips? A person suffering from agraphobia may benefit from seeing a counselor. Therapy and sometimes medication might be the most helpful in treating this phobia, but there can be some inherent problems in conducting therapy. Establishing trust with a person who suffers from agraphobia might take some time, especially if that person believes that the therapist poses a risk of sexual abuse. Sometimes group therapy can be more effective. Using a therapist of the same gender, in certain circumstances, might be easier as well, although this is not always the case. Read even more information on https://ultiblog.com/agraphobia_contreltophobia/.

Can you have Agraphobia and social anxiety? Agraphobia and social anxiety share symptoms, making them hard to diagnose. Statistics suggest that 90% of people with a social anxiety disorder have a co-occurring condition, which means having two conditions at the same time. This means that both Agraphobia and social anxiety disorder may occur together. According to a 2014 study, women are more likely to experience both disorders together compared to men.

Signs of Agraphobia: The signs and symptoms of Agraphobia can vary significantly from person to person, explains Dr Modgil. For example, someone with severe Agraphobia may be unable to leave their house, whereas someone who has mild Agraphobia may be able to live day to day without problems, but may become anxious in large venues or crowds, and therefore seek to avoid them. How to help yourself and others with Agraphobia: There are a number of ways we can help ourselves or people we love who may be battling with Agraphobia, says Dr Modgil. Due to its strong link, techniques to help in panic attack situations are a good place to start…

Association with panic attacks: Panic attacks can occur in people with Agraphobia or social anxiety disorder. A panic attack is a sudden feeling of intense fear that may not have a specific cause. With Agraphobia, you may have the intense fear that you can’t escape from somewhere like a shopping mall or crowded place, which can lead to a panic attack. With social anxiety, an anxiety-provoking situation, such as giving a speech or being in a job interview, can potentially lead to a panic attack.

Agraphobia is an intense fear of sexual abuse. A person who suffers from agraphobia is afraid of being sexually abused, raped, attacked or involved in a sexually abusive relationship to such an extent that the fear is irrational. For example, a women who suffers from agraphobia might be afraid to be alone in an elevator with any men whom she doesn’t know for fear of being sexually assaulted. Someone who suffers from this phobia might or might not have been a victim of sexual abuse or other sexual crime. Read additional information at https://ultiblog.com/.

Reliable Provestra online store today? How Does Provestra Work? Generally, this product works by boosting the user’s sexual health and performance. It mainly helps by lubricating the vagina while encouraging sexual sensation. Also, use of this libido enhancer product on a daily basis leads to hormonal balance and boosts sex drive. It is also important to mention that manufacturer values consumer’s health and this explains the reason for using natural ingredients during formulation. See more information at Provestra Pills.

Here are some of the factors that could diminish the libido for women: hormonal imbalances: the period preceding menopause, can cause hormonal changes that will lead to a marked lack of interest in sexual activity. There may also be discomforts that occur during sexual contact due to decreased ability of vaginal tissues to lubricate the area. Depression and chronic stress: When you feel depressed or stressed, your libido can decrease greatly.

After orgasm, your muscles relax and your blood pressure drops. Your clitoris might feel particularly sensitive or even painful to touch. You might experience a refractory period, during which you won’t be able to orgasm again. Some people experience multiple orgasms, but that’s not necessary for you to have a pleasurable sexual experience. The most important thing is for you to listen to your body and be comfortable. You might struggle to concentrate on anything else — even if you’re not actually having sex! That’s because sexual stimuli activates certain changes in your brain, inducing certain sex-focused brain activity. However, there’s still a lot we don’t know about how the brain works, including how the brain works during sex.

Other woman libido enhancers: The product works by intensifying sexual excitement and producing a warm, tingly feeling of anticipation. It lubricates the vagina to guarantee you maximum pleasure all the way up until climax. It’s 100% doctor endorsed , with no unpleasant side effects. Produced by a cGMP pharmaceutical grade manufacturer, it’s certainly deserving of your trust. HerSolution is a blend of natural herbs, aphrodisiacs and nutrients, including niacin, hops extract, mucuna pruriens, gingko biloba, epimedium sagitattum, and cayenne pepper. These ingredients work miracles for women who take the pill, coming with a variety of benefits: Increases sexual appetiteBoosts vaginal lubrication Intensifies genital sensationsIncreases sex anticipation and sexual fantasiesIncreases sexual arousalNaturally balances hormones. How does HerSolution work? Applying HerSolution to the genital area causes blood flow to increase by dilating the blood vessels. This enhances sensitivity to the vaginal and clitoral regions. Where can I buy HerSolution? You can get a budget-friendly monthly supply, or order a bulk purchase for as little as $36.66 per month.

Pink Venus Shot: It’s a cherry-flavored libido shot. Besides the fact that it smells like sex between minors, it contains as much caffeine as a cup of coffee, which triggered a horrible migraine because of which, ironically, I couldn’t even think about sex. I think if you are excited to have oral sex, you can consume it from your boyfriend’s tool. It’s the only sexual satisfaction someone can offer. It would be more useful if we dumped it and used the tube as a dildo. It made me feel about as sexy as I would have felt if I had watched a pigeon try to force another on the roof of a chapel at a funeral.

Provestra is a supplement designed to increase sexual desire and improve arousal. It is made without synthetic hormones, but its all-natural ingredients balance your body’s hormones and provide nutrients you may be lacking. At its core, Provestra is designed to address the issues keeping your body from desiring sex and feeling pleasure. While Provestra is marketed as a “female libido enhancement,” it actually treats many issues that some women experience for decades of their lives, including menopause and perimenopause symptoms. Menopause begins 12 months after your final period, usually after the age of 50. Perimenopause can start in your 30s and includes many of the same symptoms. Find more information at https://provestrapills.com/.

Plastic surgery research and science by Karim Sarhane right now? One-fifth to one-third of patients with traumatic injuries to their arms and legs experience nerve injury, which can be devastating. It can result in muscle weakness or numbness, prevent walking or using the arms, and reduce the ability to perform daily activities. Even with surgery, some nerve injuries never recover, and currently there are not many medical options to address this problem. In 2022, the researchers plan to perform this research on more primates to triple the size of the original group. The study can then move into phase I clinical trials for humans.

Dr. Sarhane is published in top-ranked bioengineering, neuroscience, and surgery journals. He holds a patent for a novel Nanofiber Nerve Wrap that he developed with his colleagues at the Johns Hopkins Institute for NanoBioTechnology and the Johns Hopkins Department of Neuroscience (US Patent # 10500305, December 2019). He is the recipient of many research grants and research awards, including the Best Basic Science Paper at the Johns Hopkins Residents Research Symposium, the Basic Science Research Grant Prize from the American Foundation for Surgery of the Hand, the Research Pilot Grant Prize from the Plastic Surgery Foundation, and a Scholarship Award from the American College of Surgeons. He has authored to date 46 peer-reviewed articles, 11 book chapters, 45 peer-reviewed abstracts, and has 28 national presentations. He is an elected member of the Plastic Surgery Research Council, the American Society for Reconstructive Microsurgery, the American Society for Reconstructive Transplantation, and the American Society for Peripheral Nerves.

Although numerous studies have demonstrated the benefit of IGF-1 to SCs, myocytes, and neurons in vitro and following PNI in animal models, several factors must be examined prior to proposing a treatment modality that is suitable for clinical translation. Besides efficacy, additional considerations include ease of regulatory clearance and safety. With regard to regulatory clearance, GH, Growth Hormone Releasing Hormone, and IGF-1 are already clinically available, FDA-approved drugs approved for other indications. With regards to safety, hypoglycemia is the most commonly seen short-term effect of IGF-1 use, although accumulation of body fat, coarsening of facial features, and lymphoid hyperplasia necessitating surgical correction have also been observed with long-term use (Contreras et al., 1995; Tuffaha et al., 2016b). Clinical trials investigating a link between malignancy and exogenous GH therapy have been equivocal, with multiple studies in children undergoing GH therapy demonstrating a low risk of associated malignancy. Additionally, GH therapy in adults has not been found to increase the risk of cancer (Yang et al., 2004; Xu et al., 2005; Chung et al., 2008; Renehan and Brennan, 2008; Svensson and Bengtsson, 2009; Tuffaha et al., 2016b). Given the potential systemic effects of IGF-1, a practical delivery system that can provide sustained release of bioactive IGF-1 to nerve and muscle tissue affected by PNI is of great importance. It will also be important to determine the minimum dose and duration required to achieve therapeutic efficacy.

Effects with sustained IGF-1 delivery (Karim Sarhane research) : The translation of NP- mediated delivery of water-soluble bioactive protein therapeutics has, to date, been limited in part by the complexity of the fabrication strategies. FNP is commonly used to encapsulate hydrophobic therapeutics, offering a simple, efficient, and scalable technique that enables precise tuning of particle characteristics [35]. Although the new iFNP process improves water-soluble protein loading, it is difficult to preserve the bioactivity of encapsulated proteins with this method.

The amount of time that elapses between initial nerve injury and end-organ reinnervation has consistently been shown to be the most important predictor of functional recovery following PNI (Scheib and Hoke, 2013), with proximal injuries and delayed repairs resulting in worse outcomes (Carlson et al., 1996; Tuffaha et al., 2016b). This is primarily due to denervation-induced atrophy of muscle and Schwann cells (SCs) (Fu and Gordon, 1995).

Patients who sustain peripheral nerve injuries (PNIs) are often left with debilitating sensory and motor loss. Presently, there is a lack of clinically available therapeutics that can be given as an adjunct to surgical repair to enhance the regenerative process. Insulin-like growth factor-1 (IGF-1) represents a promising therapeutic target to meet this need, given its well-described trophic and anti-apoptotic effects on neurons, Schwann cells (SCs), and myocytes. Here, we review the literature regarding the therapeutic potential of IGF-1 in PNI. We appraised the literature for the various approaches of IGF-1 administration with the aim of identifying which are the most promising in offering a pathway toward clinical application. We also sought to determine the optimal reported dosage ranges for the various delivery approaches that have been investigated.